Miraculous Spontaneous Remission: Three Individuals Overcome Rare Heart Failure

Recently, three patients with transthyretin cardiac amyloidosis (ATTR-CM) were reported to have spontaneously recovered from the condition. ATTR-CM is a rare but severe cause of restrictive cardiomyopathy, which can cause heart failure, irregular heartbeat, and other symptoms. The researchers believe that the recovery may have been due to an immune response, suggesting that antibody treatments could be effective against the condition. The three patients were unrelated older men, aged 68, 76, and 82, respectively. The recovery of cardiac amyloidosis is a significant breakthrough, as the condition is often fatal, with around half of those diagnosed with ATTR-CM dying within four years of diagnosis.

Early diagnosis and treatment may slow the progression of the disease, and people with the condition are treated to relieve the symptoms of heart failure and arrhythmias and to slow the buildup of TTR. The spontaneous recovery of these three patients is considered a “Holy Grail” of amyloidosis treatment, as it proves that a long-hoped-for cure of cardiac amyloidosis is not just speculation but is attainable and occurs in nature.