Unveiling the Link between Gut Microbes and Neurological Disorders: Exploring Potential Remedies through Fecal Transplants

Recent research has shown that there is a connection between gut microbes and neurological diseases. The gut microbiome has been implicated as a possible key susceptibility factor for neurological disorders, including Alzheimer’s disease, autism spectrum disorder, multiple sclerosis, Parkinson’s disease, and stroke. The gut-residing microbes exhibit several beneficial effects on the host at a healthy state, but in the disease or disruption state, it has been reported to be involved in the progression of several diseases, including neurological disorders. The gut has strong bidirectional communication with the brain, which is vital for maintaining the brain functions and gut homeostasis.

The gut-brain crosstalk not only maintains the healthy status but also has been implicated in the development of psychological and neurological diseases.Gut-brain crosstalk is maintained by immunological mediators, lymphocytes, neurotransmitters, microbes, and microbial metabolites. Gut microbial metabolites are transported to the CNS, where they regulate CNS cells and immune cells. Alterations in the gut microbiota and microbial metabolite production have been linked to a wide range of immune-related neurological disorders, including developmental disorders, neurodegeneration, and emotional disorders.Cures are now being sought from fecal transplants. The gut microbiota can be modified to combat neurodegeneration. The impact of gut microbes and their metabolites is manifested quite uniquely in the CNS. A healthy gut microbiota benefits the host by producing microbial metabolites and neurotransmitters for communication with the host cells, such as intestinal epithelial cells (IECs) and immune cells.